'
SCIENTIFIC SCORE
Possibly Effective
Based on 43 Researches
7.1
USERS' SCORE
Good
Based on 7 Reviews
8.6
Supplement Facts
Serving Size:  2 Soft Gels
Amount Per Serving
%DV
Calories
10
 
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
Vitamin D3 (cholecalciferol)
10 mcg (400 IU)
67%
Total Omega-3s♦
830 mg
EPA (Eicosapentaenoic Acid)
205 mg
DHA (Docosahexaenoic Acid)
480 mg

Top Medical Research Studies

9
Omega-3 lowers coronary risk
A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.
Directly related to heart disease
We explored the impact of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on heart disease through a significant study known as the VITAL trial. This study involved nearly 26,000 older adults in the U.S. and aimed to determine the effects of daily EPA supplementation on cardiovascular events over an average follow-up of 5.3 years.

Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.

This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
Read More
9
EPA helps fight heart disease
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy.
Strong evidence of EPA's benefits
We explored the effects of eicosapentaenoic acid (EPA) on heart disease, particularly diabetic cardiomyopathy (DC). This condition is a significant cause of heart failure, yet until now, effective treatment options have been limited. Our study focused on the protective role of EPA in diabetic mice induced by streptozotocin and high-fat diets.

Our findings indicate that EPA is beneficial in reducing the harmful M1-polarized macrophages in the heart. In laboratory tests, EPA showed the ability to protect heart cells from damage caused by these inflammatory cells by shifting the macrophage type from M1 to Mox, rather than to the M2 type. This is crucial since Mox polarization can help shield heart cells from the adverse effects of M1 macrophages.

Additionally, we discovered that a protein called heme oxygenase 1 (HO-1) plays a crucial role in sustaining this protective Mox phenotype. EPA promotes HO-1 levels, which in turn helps reduce M1 polarization and its damaging effects on heart cells. Even more promising, EPA was shown to enhance Mox polarization in macrophages derived from diabetic patients, indicating its potential as a treatment strategy.

Overall, our research highlights EPA and macrophage Mox polarization as innovative approaches to combat diabetic cardiomyopathy, showcasing a new avenue in the fight against heart disease.
Read More
8
Vitamin D improves heart health
The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.
Study shows vitamin D benefits
We conducted a double-blind, randomized clinical trial to explore how treating vitamin D deficiency affects heart health, specifically in patients with ischemic heart disease (IHD). In our study, we involved 44 patients aged between 40 and 65 who were dealing with low vitamin D levels. They were divided into two groups—one receiving vitamin D supplements and the other a placebo.

Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.

Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.

Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Read More

Most Useful Reviews

9.5
Vital for development
This is the only DHA I recommend to my patients. It's clean and safe, essential in the third trimester for the baby's brain, nervous system, and eyes. If you want a clever baby, buy this product. The small capsules are easy to swallow and cause minimal reflux when taken with food.
Read More
8.3
Supports pregnancy health
The quality of this Omega is excellent. I purchased it for my daughter during pregnancy, and it positively impacts the baby's development and the cardiovascular system. I wholeheartedly recommend it to others.
Read More
8.8
Improved heart health
I have been taking this Omega 3 with vitamin D for 1.5 months. Despite a month-long delivery to Khabarovsk, it was efficient. The capsules have a natural fish oil scent and are easy to swallow. I've noticed my skin remains elastic, and my hair is shinier. Most importantly, my heart has shown improvement; my arrhythmia has normalised, and I believe Omega-3's benefits in preventing heart disease are well-established. Vitamin D is vital for both mother and baby's health. Thank you, IHERB!
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 43 Researches
7.1
9
Omega-3 lowers coronary risk
A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.
Directly related to heart disease
We explored the impact of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on heart disease through a significant study known as the VITAL trial. This study involved nearly 26,000 older adults in the U.S. and aimed to determine the effects of daily EPA supplementation on cardiovascular events over an average follow-up of 5.3 years.

Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.

This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
Read More
9
Eicosapentaenoic acid improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
Directly studies heart failure treatment
We explored how eicosapentaenoic acid (a type of omega-3 fatty acid) can play a role in improving heart health, particularly in individuals with heart failure. Our analysis involved a network meta-analysis of numerous randomized controlled trials, focusing on the effects of eicosapentaenoic acid on heart function.

The findings showed that high doses of omega-3 supplements, specifically between 2000 to 4000 mg per day, taken for at least a year, can significantly enhance left ventricular ejection fraction, which is an important measure of heart function. This is encouraging news for patients struggling with heart failure, as a better ejection fraction can lead to improved heart health.

We also observed improvements in peak oxygen consumption, offering further evidence of how eicosapentaenoic acid can boost cardiac performance. Importantly, we found no significant increases in dropout rates or overall mortality among those taking omega-3 supplements compared to those not taking them. This suggests that the benefits come without added risks.

Overall, our research underscores the potential of long-term, high-dose eicosapentaenoic acid supplementation as a supportive treatment option for heart failure patients, advocating for further studies to confirm these promising results and help refine treatment recommendations.
Read More
9
EPA helps fight heart disease
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy.
Strong evidence of EPA's benefits
We explored the effects of eicosapentaenoic acid (EPA) on heart disease, particularly diabetic cardiomyopathy (DC). This condition is a significant cause of heart failure, yet until now, effective treatment options have been limited. Our study focused on the protective role of EPA in diabetic mice induced by streptozotocin and high-fat diets.

Our findings indicate that EPA is beneficial in reducing the harmful M1-polarized macrophages in the heart. In laboratory tests, EPA showed the ability to protect heart cells from damage caused by these inflammatory cells by shifting the macrophage type from M1 to Mox, rather than to the M2 type. This is crucial since Mox polarization can help shield heart cells from the adverse effects of M1 macrophages.

Additionally, we discovered that a protein called heme oxygenase 1 (HO-1) plays a crucial role in sustaining this protective Mox phenotype. EPA promotes HO-1 levels, which in turn helps reduce M1 polarization and its damaging effects on heart cells. Even more promising, EPA was shown to enhance Mox polarization in macrophages derived from diabetic patients, indicating its potential as a treatment strategy.

Overall, our research highlights EPA and macrophage Mox polarization as innovative approaches to combat diabetic cardiomyopathy, showcasing a new avenue in the fight against heart disease.
Read More
9
Omega-3s and heart disease risk
Circulating Omega-3 Polyunsaturated Fatty Acids Levels in Coronary Heart Disease: Pooled Analysis of 36 Observational Studies.
Considered broader omega-3 impacts
We explored the connection between omega-3 fatty acids, particularly eicosapentaenoic acid (EPA), and coronary heart disease (CHD). Our analysis reviewed 36 observational studies that included both prospective and retrospective designs, offering a well-rounded look at how different omega-3 levels may impact heart health.

The results highlighted a clear trend: higher levels of various omega-3 fatty acids, including EPA, were associated with a reduced risk of developing CHD. We noted that groups with elevated omega-3 levels displayed lower relative risks—indicating that maintaining a sufficient intake of these fatty acids could be beneficial for heart health.

Interestingly, our findings revealed that patients with CHD had significantly lower omega-3 levels compared to healthier individuals. Moreover, specific subtypes of omega-3, such as EPA and DHA, demonstrated a particularly strong inverse relationship with both fatal and non-fatal heart disease events.

Overall, this analysis shows that omega-3 polyunsaturated fatty acids, especially EPA and DHA, are linked to a decreased risk of CHD. Our findings support the idea that integrating these nutrients into our diets may provide protective benefits against heart disease.
Read More
9
Docosahexaenoic acid benefits heart health
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
Moderate relevance for DHA impact
We aimed to understand how docosahexaenoic acid (DHA), a form of omega-3 polyunsaturated fatty acid (PUFA), could benefit patients suffering from heart failure. Our investigation drew on a network meta-analysis that included data from 14 randomized controlled trials, comprising 9,075 participants. This analysis focused particularly on the effects of DHA and other omega-3s on heart health metrics.

The findings revealed that high doses of omega-3 PUFA supplementation, specifically between 2000 to 4000 mg daily for at least one year, significantly improved heart function. We observed notable enhancements in the left ventricular ejection fraction and peak oxygen consumption, crucial indicators of heart performance, when compared to control groups.

Interestingly, lower doses and shorter periods of supplementation did not yield the same positive results. Importantly, we found no significant increase in dropout rates or overall mortality among those taking omega-3 PUFAs compared to those who were not. This suggests that high-dose DHA supplementation can enhance cardiac function without raising safety concerns.

Overall, our research indicates that long-term, high-dose DHA can be a beneficial strategy in managing heart failure. However, we recognize that further well-designed trials with stringent criteria are needed to validate these findings fully.
Read More

User Reviews

USERS' SCORE
Good
Based on 7 Reviews
8.6
9.5
Vital for development
This is the only DHA I recommend to my patients. It's clean and safe, essential in the third trimester for the baby's brain, nervous system, and eyes. If you want a clever baby, buy this product. The small capsules are easy to swallow and cause minimal reflux when taken with food.
Read More
8.8
Improved heart health
I have been taking this Omega 3 with vitamin D for 1.5 months. Despite a month-long delivery to Khabarovsk, it was efficient. The capsules have a natural fish oil scent and are easy to swallow. I've noticed my skin remains elastic, and my hair is shinier. Most importantly, my heart has shown improvement; my arrhythmia has normalised, and I believe Omega-3's benefits in preventing heart disease are well-established. Vitamin D is vital for both mother and baby's health. Thank you, IHERB!
Read More
8.8
Increased energy levels
I’m in my seventh month and after a week of using this, I’ve noticed more energy and less joint pain. I plan to continue until birth and will switch to the postpartum version, which has more Vitamin D to improve mood. Praise be to God for this improvement!
8.8
Effective Omega quality
I highly recommend this pure omega for pregnant and lactating women. The smell is off-putting, but there’s no unpleasant taste or burping during use. My skin is no longer dry, and my tests show excellent results. This product supports heart health and enhances overall wellbeing during pregnancy.
Read More
8.8
Essential for mothers
I spent time researching and chose this Omega 3. Its formulation combines anchovy and sardine, ensuring low mercury levels, plus it contains Vitamin D. The capsules are convenient, tasteless, and free from belching. I take two daily, and it provides significant benefits for both mother and baby's health.
Read More
image